The ubiquitination status of the glucagon receptor determines signal bias

The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. Glu...

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Detalles Bibliográficos
Autores principales: Kaur, Suneet, Sokrat, Badr, Capozzi, Megan E., El, Kimberley, Bai, Yushi, Jazic, Aeva, Han, Bridgette, Krishna Kumar, Kaavya, D'Alessio, David A., Campbell, Jonathan E., Bouvier, Michel, Shenoy, Sudha K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200972/
https://www.ncbi.nlm.nih.gov/pubmed/37037304
http://dx.doi.org/10.1016/j.jbc.2023.104690

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10200972/
https://www.ncbi.nlm.nih.gov/pubmed/37037304
http://dx.doi.org/10.1016/j.jbc.2023.104690

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