B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children

BACKGROUND: SLE is likely triggered by gene–environment interactions. We have shown that most SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in lymphocytes, suggesting genetic risk is exerted through altered gene regulation. Data r...

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Detalles Bibliográficos
Autores principales: Hui-Yuen, Joyce, Jiang, Kaiyu, Malkiel, Susan, Eberhard, Barbara Anne, Walters, Heather, Diamond, Betty, Jarvis, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201247/
https://www.ncbi.nlm.nih.gov/pubmed/37202122
http://dx.doi.org/10.1136/lupus-2023-000921

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201247/
https://www.ncbi.nlm.nih.gov/pubmed/37202122
http://dx.doi.org/10.1136/lupus-2023-000921

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