A hybrid structure determination approach to investigate the druggability of the nucleocapsid protein of SARS-CoV-2

The pandemic caused by SARS-CoV-2 has called for concerted efforts to generate new insights into the biology of betacoronaviruses to inform drug screening and development. Here, we establish a workflow to determine the RNA recognition and druggability of the nucleocapsid N-protein of SARS-CoV-2, a h...

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Detalles Bibliográficos
Autores principales: Padroni, Giacomo, Bikaki, Maria, Novakovic, Mihajlo, Wolter, Antje C, Rüdisser, Simon H, Gossert, Alvar D, Leitner, Alexander, Allain, Frederic H-T
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
RNA and RNA-protein complexes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201421/
https://www.ncbi.nlm.nih.gov/pubmed/36928389
http://dx.doi.org/10.1093/nar/gkad195

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201421/
https://www.ncbi.nlm.nih.gov/pubmed/36928389
http://dx.doi.org/10.1093/nar/gkad195

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