Catalytic mechanism and pH dependence of a methyltransferase ribozyme (MTR1) from computational enzymology

A methyltransferase ribozyme (MTR1) was selected in vitro to catalyze alkyl transfer from exogenous O(6)-methylguanine (O(6)mG) to a target adenine N1, and recently, high-resolution crystal structures have become available. We use a combination of classical molecular dynamics, ab initio quantum mech...

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Detalles Bibliográficos
Autores principales: McCarthy, Erika, Ekesan, Şölen, Giese, Timothy J, Wilson, Timothy J, Deng, Jie, Huang, Lin, Lilley, David M J, York, Darrin M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201425/
https://www.ncbi.nlm.nih.gov/pubmed/37070188
http://dx.doi.org/10.1093/nar/gkad260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201425/
https://www.ncbi.nlm.nih.gov/pubmed/37070188
http://dx.doi.org/10.1093/nar/gkad260

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