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Catalytic mechanism and pH dependence of a methyltransferase ribozyme (MTR1) from computational enzymology
A methyltransferase ribozyme (MTR1) was selected in vitro to catalyze alkyl transfer from exogenous O(6)-methylguanine (O(6)mG) to a target adenine N1, and recently, high-resolution crystal structures have become available. We use a combination of classical molecular dynamics, ab initio quantum mech...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201425/ https://www.ncbi.nlm.nih.gov/pubmed/37070188 http://dx.doi.org/10.1093/nar/gkad260 |