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PGC-1α overexpression is not sufficient to mitigate cancer cachexia in either male or female mice
Cancer cachexia (CC) accounts for 20%–40% of cancer-related deaths. Mitochondrial aberrations have been shown to precede muscle atrophy in different atrophy models, including cancer. Therefore, this study investigated potential protection from the cachectic phenotype through overexpression of peroxi...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201462/ https://www.ncbi.nlm.nih.gov/pubmed/35700525 http://dx.doi.org/10.1139/apnm-2022-0086 |