Condensation of the β‐cell secretory granule luminal cargoes pro/insulin and ICA512 RESP18 homology domain

ICA512/PTPRN is a receptor tyrosine‐like phosphatase implicated in the biogenesis and turnover of the insulin secretory granules (SGs) in pancreatic islet beta cells. Previously we found biophysical evidence that its luminal RESP18 homology domain (RESP18HD) forms a biomolecular condensate and inter...

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Detalles Bibliográficos
Autores principales: Toledo, Pamela L., Vazquez, Diego S., Gianotti, Alejo R., Abate, Milagros B., Wegbrod, Carolin, Torkko, Juha M., Solimena, Michele, Ermácora, Mario R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201709/
https://www.ncbi.nlm.nih.gov/pubmed/37159024
http://dx.doi.org/10.1002/pro.4649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201709/
https://www.ncbi.nlm.nih.gov/pubmed/37159024
http://dx.doi.org/10.1002/pro.4649

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