The BET PROTAC inhibitor dBET6 protects against retinal degeneration and inhibits the cGAS-STING in response to light damage

BACKGROUND: Chronic inflammation significantly contributes to photoreceptor death in blinding retinal diseases such as age-related macular degeneration (AMD) and retinitis pigmentosa (RP). Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that act as key proinflammatory fact...

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Detalles Bibliográficos
Autores principales: Zhu, Xingfei, Liu, Wei, Tang, Xiangcheng, Chen, Yulin, Ge, Xiangyu, Ke, Qin, Liang, Xingmiao, Gan, Yuwen, Zheng, Yingfeng, Zou, Ming, Deng, Mi, Liu, Yizhi, Li, David Wan-Cheng, Gong, Lili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201800/
https://www.ncbi.nlm.nih.gov/pubmed/37217935
http://dx.doi.org/10.1186/s12974-023-02804-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10201800/
https://www.ncbi.nlm.nih.gov/pubmed/37217935
http://dx.doi.org/10.1186/s12974-023-02804-y

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