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Endosomal trafficking of two-pore K(+) efflux channel TWIK2 to plasmalemma mediates NLRP3 inflammasome activation and inflammatory injury

Potassium efflux via the two-pore K(+) channel TWIK2 is a requisite step for the activation of NLRP3 inflammasome, however, it remains unclear how K(+) efflux is activated in response to select cues. Here, we report that during homeostasis, TWIK2 resides in endosomal compartments. TWIK2 is transport...

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Detalles Bibliográficos
Autores principales: Huang, Long Shuang, Anas, Mohammad, Xu, Jingsong, Zhou, Bisheng, Toth, Peter T, Krishnan, Yamuna, Di, Anke, Malik, Asrar B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202452/
https://www.ncbi.nlm.nih.gov/pubmed/37158595
http://dx.doi.org/10.7554/eLife.83842