Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium

Multiciliated cell loss is a hallmark of airway epithelial remodeling in chronic inflammatory airway diseases including cystic fibrosis (CF), asthma, and chronic obstructive pulmonary disease. It disrupts mucociliary clearance, which fuels disease progression. Effective clearance requires an optimal...

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Detalles Bibliográficos
Autores principales: Vladar, Eszter K., Kunimoto, Koshi, Rojas-Hernandez, Laura S., Spano, Jacquelyn M., Sellers, Zachary M., Joo, Nam Soo, Cooney, Riley A., Axelrod, Jeffrey D., Milla, Carlos E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202488/
https://www.ncbi.nlm.nih.gov/pubmed/37039381
http://dx.doi.org/10.1152/ajplung.00382.2022

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202488/
https://www.ncbi.nlm.nih.gov/pubmed/37039381
http://dx.doi.org/10.1152/ajplung.00382.2022

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