Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells

Perturbing expression is a powerful way to understand the role of individual genes, but can be challenging in important models. CRISPR-Cas screens in human induced pluripotent stem cells (iPSCs) are of limited efficiency due to DNA break-induced stress, while the less stressful silencing with an ina...

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Detalles Bibliográficos
Autores principales: Usluer, Sunay, Hallast, Pille, Crepaldi, Luca, Zhou, Yan, Urgo, Katie, Dincer, Cansu, Su, Jing, Noell, Guillaume, Alasoo, Kaur, El Garwany, Omar, Gerety, Sebastian S., Newman, Ben, Dovey, Oliver M., Parts, Leopold
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202655/
https://www.ncbi.nlm.nih.gov/pubmed/37028423
http://dx.doi.org/10.1016/j.stemcr.2023.03.008

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202655/
https://www.ncbi.nlm.nih.gov/pubmed/37028423
http://dx.doi.org/10.1016/j.stemcr.2023.03.008

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