IRX5 promotes DNA damage repair and activation of hair follicle stem cells

The molecular mechanisms allowing hair follicles to periodically activate their stem cells (HFSCs) are incompletely characterized. Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5(−/−) mice have delayed anagen onset, with increased DNA damage and diminished HFSC...

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Detalles Bibliográficos
Autores principales: Chen, Jefferson K., Wiedemann, Julie, Nguyen, Ly, Lin, Zhongqi, Tahir, Mahum, Hui, Chi-Chung, Plikus, Maksim V., Andersen, Bogi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202659/
https://www.ncbi.nlm.nih.gov/pubmed/37084727
http://dx.doi.org/10.1016/j.stemcr.2023.03.013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202659/
https://www.ncbi.nlm.nih.gov/pubmed/37084727
http://dx.doi.org/10.1016/j.stemcr.2023.03.013

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