Cargando…

IRX5 promotes DNA damage repair and activation of hair follicle stem cells

The molecular mechanisms allowing hair follicles to periodically activate their stem cells (HFSCs) are incompletely characterized. Here, we identify the transcription factor IRX5 as a promoter of HFSC activation. Irx5(−/−) mice have delayed anagen onset, with increased DNA damage and diminished HFSC...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Jefferson K., Wiedemann, Julie, Nguyen, Ly, Lin, Zhongqi, Tahir, Mahum, Hui, Chi-Chung, Plikus, Maksim V., Andersen, Bogi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202659/ https://www.ncbi.nlm.nih.gov/pubmed/37084727 http://dx.doi.org/10.1016/j.stemcr.2023.03.013

Ejemplares similares

MON-229 IRX3 and IRX5 Regulate Downstream Targets that Promote Ovarian Follicle Integrity in Mice
por: Fu, Anqi, et al.
Publicado: (2019)

Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries
por: Fu, Anqi, et al.
Publicado: (2018)

Modelling Hair Follicle Growth Dynamics as an Excitable Medium
por: Murray, Philip J., et al.
Publicado: (2012)

Irx3 and Irx5 - Novel Regulatory Factors of Postnatal Hypothalamic Neurogenesis
por: Dou, Zhengchao, et al.
Publicado: (2021)

Circadian Clock Genes Contribute to the Regulation of Hair Follicle Cycling
por: Lin, Kevin K., et al.
Publicado: (2009)

Intrinsic ROS Drive Hair Follicle Cycle Progression by Modulating DNA Damage and Repair and Subsequently Hair Follicle Apoptosis and Macrophage Polarization
por: Liu, Mingsheng, et al.
Publicado: (2022)

A multi-scale model for hair follicles reveals heterogeneous domains driving rapid spatiotemporal hair growth patterning
por: Wang, Qixuan, et al.
Publicado: (2017)

Principles and mechanisms of regeneration in the mouse model for wound‐induced hair follicle neogenesis
por: Wang, Xiaojie, et al.
Publicado: (2015)

A guide to studying human hair follicle cycling in vivo
por: Oh, Ji Won, et al.
Publicado: (2016)

Site-Directed Mutagenesis of IRX9, IRX9L and IRX14 Proteins Involved in Xylan Biosynthesis: Glycosyltransferase Activity Is Not Required for IRX9 Function in Arabidopsis
por: Ren, Yanfang, et al.
Publicado: (2014)

Ectopic expression of Irx3 and Irx5 in the paraventricular nucleus of the hypothalamus contributes to defects in Sim1 haploinsufficiency
por: Son, Joe Eun, et al.
Publicado: (2021)

Clock genes, hair growth and aging
por: Geyfman, Mikhail, et al.
Publicado: (2010)

The Iroquois homeobox proteins IRX3 and IRX5 have distinct roles in Wilms tumour development and human nephrogenesis
por: Holmquist Mengelbier, Linda, et al.
Publicado: (2018)

An unusual xylan in Arabidopsis primary cell walls is synthesised by GUX3, IRX9L, IRX10L and IRX14
por: Mortimer, Jenny C, et al.
Publicado: (2015)

CD133 expression correlates with membrane beta-catenin and e-cadherin loss from human hair follicle placodes during morphogenesis
por: Gay, Denise, et al.
Publicado: (2014)

Three Novel Rice Genes Closely Related to the Arabidopsis IRX9, IRX9L, and IRX14 Genes and Their Roles in Xylan Biosynthesis
por: Chiniquy, Dawn, et al.
Publicado: (2013)

Depletion of CD200+ Hair Follicle Stem Cells in Human Prematurely Gray Hair Follicles
por: Mohanty, Sujata, et al.
Publicado: (2013)

Platelet sonicates activate hair follicle stem cells and mediate enhanced hair follicle regeneration
por: Zhu, Meishu, et al.
Publicado: (2019)

The Hematopoietic TALE-Code Shows Normal Activity of IRX1 in Myeloid Progenitors and Reveals Ectopic Expression of IRX3 and IRX5 in Acute Myeloid Leukemia
por: Nagel, Stefan, et al.
Publicado: (2022)

Hedgehog stimulates hair follicle neogenesis by creating inductive dermis during murine skin wound healing
por: Lim, Chae Ho, et al.
Publicado: (2018)

Immunohistochemical study of hair follicle stem cells in regenerated hair follicles induced by Wnt10b
por: Zhang, Yiming, et al.
Publicado: (2016)

Murine interfollicular epidermal differentiation is gradualistic with GRHL3 controlling progression from stem to transition cell states
por: Lin, Ziguang, et al.
Publicado: (2020)

Hair follicle-derived mesenchymal stem cells decrease alopecia areata mouse hair loss and reduce inflammation around the hair follicle
por: Deng, Weiyue, et al.
Publicado: (2021)

Hair Graying Regulators Beyond Hair Follicle
por: Chen, Jing, et al.
Publicado: (2022)

IRX1 hypomethylation in osteosarcoma metastasis
por: Lu, Jinchang, et al.
Publicado: (2015)

Aging of hair follicle stem cells and their niches
por: Jang, Hansaem, et al.
Publicado: (2023)

Hair follicle-targeting drug delivery strategies for the management of hair follicle-associated disorders
por: Gu, Yueting, et al.
Publicado: (2022)

Irx3 is required for postnatal maturation of the mouse ventricular conduction system
por: Kim, Kyoung-Han, et al.
Publicado: (2016)

Hormonal Effects on Hair Follicles
por: Grymowicz, Monika, et al.
Publicado: (2020)

Alpinetin promotes hair regeneration via activating hair follicle stem cells
por: Fan, Xiaojiao, et al.
Publicado: (2022)

Induced pluripotent stem cells from human hair follicle keratinocytes as a potential source for in vitro hair follicle cloning
por: Lim, Sheng Jye, et al.
Publicado: (2016)

IL-36α Promoted Wound Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation
por: Gong, Lin, et al.
Publicado: (2020)

Hair follicle associated pluripotent (HAP) stem cells jump from transplanted whiskers to pelage follicles and stimulate hair growth
por: Obara, Koya, et al.
Publicado: (2022)

Evolutionary history of the iroquois/Irx genes in metazoans
por: Kerner, Pierre, et al.
Publicado: (2009)

Human obesity: FTO, IRX3, or both?()
por: Cedernaes, Jonathan, et al.
Publicado: (2014)

Histological characteristics of hair follicles at different hair cycle and in vitro modeling of hair follicle-associated cells of yak (Bos grunniens)
por: Liao, Bo, et al.
Publicado: (2023)

Hair Follicle Stem Cells: A New Arena
por: Gude, Dilip
Publicado: (2011)

Editorial: Hair Follicle Stem Cell Regeneration in Aging
por: Lei, Mingxing, et al.
Publicado: (2021)

Regulation of signaling pathways in hair follicle stem cells
por: Wang, Xiaoxiang, et al.
Publicado: (2022)

β-Catenin Signaling Evokes Hair Follicle Senescence by Accelerating the Differentiation of Hair Follicle Mesenchymal Progenitors
por: Han, Jimin, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1kr00eddnbbd42plvuttcilt6q