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Small lipid droplets are rigid enough to indent a nucleus, dilute the lamina, and cause rupture

The nucleus in many cell types is a stiff organelle, but fat-filled lipid droplets (FDs) in cytoplasm are seen to indent and displace the nucleus. FDs are phase-separated liquids with a poorly understood interfacial tension γ that determines how FDs interact with other organelles. Here, micron-sized...

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Detalles Bibliográficos
Autores principales: Ivanovska, Irena L., Tobin, Michael P., Bai, Tianyi, Dooling, Lawrence J., Discher, Dennis E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202833/
https://www.ncbi.nlm.nih.gov/pubmed/37212777
http://dx.doi.org/10.1083/jcb.202208123