Structural basis for substrate and inhibitor recognition of human multidrug transporter MRP4

Human multidrug resistance protein 4 (hMRP4, also known as ABCC4), with a representative topology of the MRP subfamily, translocates various substrates across the membrane and contributes to the development of multidrug resistance. However, the underlying transport mechanism of hMRP4 remains unclear...

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Detalles Bibliográficos
Autores principales: Huang, Ying, Xue, Chenyang, Wang, Liangdong, Bu, Ruiqian, Mu, Jianqiang, Wang, Yong, Liu, Zhongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202912/
https://www.ncbi.nlm.nih.gov/pubmed/37217525
http://dx.doi.org/10.1038/s42003-023-04935-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10202912/
https://www.ncbi.nlm.nih.gov/pubmed/37217525
http://dx.doi.org/10.1038/s42003-023-04935-7

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