A new polygenic score for refractive error improves detection of children at risk of high myopia but not the prediction of those at risk of myopic macular degeneration

BACKGROUND: High myopia (HM), defined as a spherical equivalent refractive error (SER) ≤ −6.00 diopters (D), is a leading cause of sight impairment, through myopic macular degeneration (MMD). We aimed to derive an improved polygenic score (PGS) for predicting children at risk of HM and to test if a...

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Detalles Bibliográficos
Autores principales: Clark, Rosie, Lee, Samantha Sze-Yee, Du, Ran, Wang, Yining, Kneepkens, Sander C.M., Charng, Jason, Huang, Yu, Hunter, Michael L., Jiang, Chen, Tideman, J.Willem L., Melles, Ronald B., Klaver, Caroline C.W., Mackey, David A., Williams, Cathy, Choquet, Hélène, Ohno-Matsui, Kyoko, Guggenheim, Jeremy A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203044/
https://www.ncbi.nlm.nih.gov/pubmed/37055258
http://dx.doi.org/10.1016/j.ebiom.2023.104551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203044/
https://www.ncbi.nlm.nih.gov/pubmed/37055258
http://dx.doi.org/10.1016/j.ebiom.2023.104551

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