Efficient CRISPR/Cas9-Mediated BAX Gene Ablation in CHO Cells To Impair Apoptosis and Enhance Recombinant Protein Production

BACKGROUND: Despite recent advances in recombinant biotherapeutics production using CHO cells, their productivity remains lower than industrial needs, mainly due to apoptosis. OBJECTIVES: Present study aimed to exploit CRISPR/Cas9 technology to specifically disrupt the BAX gene to attenuate apoptosi...

Descripción completa

Detalles Bibliográficos
Autores principales: Rahimi, Amirabbas, Karimipoor, Morteza, Mahdian, Reza, Alipour, Atefeh, Hosseini, Saadi, Mohammadi, Marzieh, Kaghazian, Hooman, Abbasi, Abdolrahim, Shahsavarani, Hosein, Shokrgozar, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Institute of Genetic Engineering and Biotechnology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203183/
https://www.ncbi.nlm.nih.gov/pubmed/37228627
http://dx.doi.org/10.30498/ijb.2023.343428.3388

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203183/
https://www.ncbi.nlm.nih.gov/pubmed/37228627
http://dx.doi.org/10.30498/ijb.2023.343428.3388

Ejemplares similares