Vitamin D inhibits osteosarcoma by reprogramming nonsense-mediated RNA decay and SNAI2-mediated epithelial-to-mesenchymal transition

Osteosarcomas are immune-resistant and metastatic as a result of elevated nonsense-mediated RNA decay (NMD), reactive oxygen species (ROS), and epithelial-to-mesenchymal transition (EMT). Although vitamin D has anti-cancer effects, its effectiveness and mechanism of action against osteosarcomas are...

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Detalles Bibliográficos
Autores principales: Capobianco, Enrico, McGaughey, Vanessa, Seraphin, Gerbenn, Heckel, John, Rieger, Sandra, Lisse, Thomas S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203545/
https://www.ncbi.nlm.nih.gov/pubmed/37228489
http://dx.doi.org/10.3389/fonc.2023.1188641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10203545/
https://www.ncbi.nlm.nih.gov/pubmed/37228489
http://dx.doi.org/10.3389/fonc.2023.1188641

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