Synthetic Approaches to a Key Pyridone-carboxylic Acid Precursor Common to the HIV-1 Integrase Strand Transfer Inhibitors Dolutegravir, Bictegravir, and Cabotegravir

[Image: see text] Dolutegravir (DTG), Bictegravir (BIC), and Cabotegravir (CAB) are the second-generation integrase strand transfer inhibitors (INSTIs) that have been FDA-approved for the treatment of HIV-1 infection. Preparation of these INSTIs utilizes the common intermediate 1-(2,2-dimethoxyethyl...

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Detalles Bibliográficos
Autores principales: Mahajan, Pankaj S., Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204085/
https://www.ncbi.nlm.nih.gov/pubmed/37229216
http://dx.doi.org/10.1021/acs.oprd.3c00063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204085/
https://www.ncbi.nlm.nih.gov/pubmed/37229216
http://dx.doi.org/10.1021/acs.oprd.3c00063

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