Genomic hallmarks and therapeutic implications of G0 cell cycle arrest in cancer

BACKGROUND: Therapy resistance in cancer is often driven by a subpopulation of cells that are temporarily arrested in a non-proliferative G0 state, which is difficult to capture and whose mutational drivers remain largely unknown. RESULTS: We develop methodology to robustly identify this state from...

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Detalles Bibliográficos
Autores principales: Wiecek, Anna J., Cutty, Stephen J., Kornai, Daniel, Parreno-Centeno, Mario, Gourmet, Lucie E., Tagliazucchi, Guidantonio Malagoli, Jacobson, Daniel H., Zhang, Ping, Xiong, Lingyun, Bond, Gareth L., Barr, Alexis R., Secrier, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204193/
https://www.ncbi.nlm.nih.gov/pubmed/37221612
http://dx.doi.org/10.1186/s13059-023-02963-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204193/
https://www.ncbi.nlm.nih.gov/pubmed/37221612
http://dx.doi.org/10.1186/s13059-023-02963-4

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