High levels of endothelial ICAM-1 prohibit natalizumab mediated abrogation of CD4(+) T cell arrest on the inflamed BBB under flow in vitro

INTRODUCTION: The humanized anti-α4 integrin blocking antibody natalizumab (NTZ) is an effective treatment for relapsing–remitting multiple sclerosis (RRMS) that is associated with the risk of progressive multifocal leukoencephalopathy (PML). While extended interval dosing (EID) of NTZ reduces the r...

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Detalles Bibliográficos
Autores principales: Soldati, Sasha, Bär, Alexander, Vladymyrov, Mykhailo, Glavin, Dale, McGrath, James L., Gosselet, Fabien, Nishihara, Hideaki, Goelz, Susan, Engelhardt, Britta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204262/
https://www.ncbi.nlm.nih.gov/pubmed/37221552
http://dx.doi.org/10.1186/s12974-023-02797-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204262/
https://www.ncbi.nlm.nih.gov/pubmed/37221552
http://dx.doi.org/10.1186/s12974-023-02797-8

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