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Graph construction method impacts variation representation and analyses in a bovine super-pangenome

BACKGROUND: Several models and algorithms have been proposed to build pangenomes from multiple input assemblies, but their impact on variant representation, and consequently downstream analyses, is largely unknown. RESULTS: We create multi-species super-pangenomes using pggb, cactus, and minigraph w...

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Detalles Bibliográficos
Autores principales: Leonard, Alexander S., Crysnanto, Danang, Mapel, Xena M., Bhati, Meenu, Pausch, Hubert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204317/
https://www.ncbi.nlm.nih.gov/pubmed/37217946
http://dx.doi.org/10.1186/s13059-023-02969-y