Microglia degrade Tau oligomers deposit via purinergic P2Y12-associated podosome and filopodia formation and induce chemotaxis

BACKGROUND: Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity. Microglia are the immune cells in the central nervous system, sense the extracellular...

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Detalles Bibliográficos
Autores principales: Chinnathambi, Subashchandrabose, Das, Rashmi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204346/
https://www.ncbi.nlm.nih.gov/pubmed/37221563
http://dx.doi.org/10.1186/s13578-023-01028-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204346/
https://www.ncbi.nlm.nih.gov/pubmed/37221563
http://dx.doi.org/10.1186/s13578-023-01028-0

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