Mutant Isocitrate Dehydrogenase 1 Expression Enhances Response of Gliomas to the Histone Deacetylase Inhibitor Belinostat

Histone deacetylase inhibitors (HDACis) are drugs that target the epigenetic state of cells by modifying the compaction of chromatin through effects on histone acetylation. Gliomas often harbor a mutation of isocitrate dehydrogenase (IDH) 1 or 2 that leads to changes in their epigenetic state presen...

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Detalles Bibliográficos
Autores principales: Chang, Chi-Ming, Ramesh, Karthik K., Huang, Vicki, Gurbani, Saumya, Kleinberg, Lawrence R., Weinberg, Brent D., Shim, Hyunsuk, Shu, Hui-Kuo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204413/
https://www.ncbi.nlm.nih.gov/pubmed/37218937
http://dx.doi.org/10.3390/tomography9030077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204413/
https://www.ncbi.nlm.nih.gov/pubmed/37218937
http://dx.doi.org/10.3390/tomography9030077

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