Cellular and transcriptional impacts of Janus kinase and/or IFN-gamma inhibition in a mouse model of primary hemophagocytic lymphohistiocytosis

BACKGROUND: Primary hemophagocytic lymphohistiocytosis (pHLH) is an inherited inflammatory syndrome driven by the exuberant activation of interferon-gamma (IFNg)-producing CD8 T cells. Towards this end, ruxolitinib treatment or IFNg neutralization (aIFNg) lessens immunopathology in a model of pHLH i...

Descripción completa

Detalles Bibliográficos
Autores principales: Albeituni, Sabrin, Oak, Ninad, Tillman, Heather S., Stroh, Alexa, Keenan, Camille, Bloom, Mackenzie, Nichols, Kim E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204641/
https://www.ncbi.nlm.nih.gov/pubmed/37228616
http://dx.doi.org/10.3389/fimmu.2023.1137037

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10204641/
https://www.ncbi.nlm.nih.gov/pubmed/37228616
http://dx.doi.org/10.3389/fimmu.2023.1137037

Ejemplares similares