Modular antibodies reveal DNA damage-induced mono-ADP-ribosylation as a second wave of PARP1 signaling

PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence of mono-ADP-ribosylation upon DNA damage, it was unknown whet...

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Detalles Bibliográficos
Autores principales: Longarini, Edoardo José, Dauben, Helen, Locatelli, Carolina, Wondisford, Anne R., Smith, Rebecca, Muench, Charlotte, Kolvenbach, Andreas, Lynskey, Michelle Lee, Pope, Alexis, Bonfiglio, Juan José, Jurado, Eva Pinto, Fajka-Boja, Roberta, Colby, Thomas, Schuller, Marion, Ahel, Ivan, Timinszky, Gyula, O’Sullivan, Roderick J., Huet, Sébastien, Matic, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Technology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205078/
https://www.ncbi.nlm.nih.gov/pubmed/37116497
http://dx.doi.org/10.1016/j.molcel.2023.03.027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205078/
https://www.ncbi.nlm.nih.gov/pubmed/37116497
http://dx.doi.org/10.1016/j.molcel.2023.03.027

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