DNA supercoiling restricts the transcriptional bursting of neighboring eukaryotic genes

DNA supercoiling has emerged as a major contributor to gene regulation in bacteria, but how DNA supercoiling impacts transcription dynamics in eukaryotes is unclear. Here, using single-molecule dual-color nascent transcription imaging in budding yeast, we show that transcriptional bursting of diverg...

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Detalles Bibliográficos
Autores principales: Patel, Heta P., Coppola, Stefano, Pomp, Wim, Aiello, Umberto, Brouwer, Ineke, Libri, Domenico, Lenstra, Tineke L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205079/
https://www.ncbi.nlm.nih.gov/pubmed/37207624
http://dx.doi.org/10.1016/j.molcel.2023.04.015

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205079/
https://www.ncbi.nlm.nih.gov/pubmed/37207624
http://dx.doi.org/10.1016/j.molcel.2023.04.015

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