MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

mTORC1 is the key rheostat controlling the cellular metabolic state. Of the various inputs to mTORC1, the most potent effector of intracellular nutrient status is amino acid supply. Despite an established role for MAP4K3 in promoting mTORC1 activation in the presence of amino acids, the signaling pa...

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Detalles Bibliográficos
Autores principales: Branch, Mary Rose, Hsu, Cynthia L, Ohnishi, Kohta, Shen, Wen-Chuan, Lee, Elian, Meisenhelder, Jill, Winborn, Brett, Sopher, Bryce L, Taylor, J Paul, Hunter, Tony, La Spada, Albert R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205607/
https://www.ncbi.nlm.nih.gov/pubmed/37221017
http://dx.doi.org/10.26508/lsa.202201525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205607/
https://www.ncbi.nlm.nih.gov/pubmed/37221017
http://dx.doi.org/10.26508/lsa.202201525

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