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Early events in amyloid-β self-assembly probed by time-resolved solid state NMR and light scattering

Self-assembly of amyloid-β peptides leads to oligomers, protofibrils, and fibrils that are likely instigators of neurodegeneration in Alzheimer’s disease. We report results of time-resolved solid state nuclear magnetic resonance (ssNMR) and light scattering experiments on 40-residue amyloid-β (Aβ40)...

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Detalles Bibliográficos
Autores principales: Jeon, Jaekyun, Yau, Wai-Ming, Tycko, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205749/
https://www.ncbi.nlm.nih.gov/pubmed/37221174
http://dx.doi.org/10.1038/s41467-023-38494-6