Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture

Beetroot is a homodimeric in vitro selected RNA that binds and activates DFAME, a conditional fluorophore derived from GFP. It is 70% sequence-identical to the previously characterized homodimeric aptamer Corn, which binds one molecule of its cognate fluorophore DFHO at its interprotomer interface....

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Detalles Bibliográficos
Autores principales: Passalacqua, Luiz F. M., Starich, Mary R., Link, Katie A., Wu, Jiahui, Knutson, Jay R., Tjandra, Nico, Jaffrey, Samie R., Ferré-D’Amaré, Adrian R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205801/
https://www.ncbi.nlm.nih.gov/pubmed/37221204
http://dx.doi.org/10.1038/s41467-023-38683-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10205801/
https://www.ncbi.nlm.nih.gov/pubmed/37221204
http://dx.doi.org/10.1038/s41467-023-38683-3

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