Antidepressant-like activity of a brain penetrant HCN channel inhibitor in mice

Changes in Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) channel function have been linked to depressive-like traits, making them potential drug targets. However, there is currently no peer-reviewed data supporting the use of a small molecule modulator of HCN channels in depression treat...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinares-Garcia, Paulo, Spyrou, James, McKenzie, Chaseley E., Forster, Ian C., Soh, Ming S., Mohamed Syazwan, Erlina, Atif, Mohammed, Reid, Christopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206048/
https://www.ncbi.nlm.nih.gov/pubmed/37234718
http://dx.doi.org/10.3389/fphar.2023.1159527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206048/
https://www.ncbi.nlm.nih.gov/pubmed/37234718
http://dx.doi.org/10.3389/fphar.2023.1159527

Ejemplares similares