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A graph-based machine learning framework identifies critical properties of FVIII that lead to hemophilia A

Introduction: Blood coagulation is an essential process to cease bleeding in humans and other species. This mechanism is characterized by a molecular cascade of more than a dozen components activated after an injury to a blood vessel. In this process, the coagulation factor VIII (FVIII) is a master...

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Detalles Bibliográficos
Autores principales: Ferreira, Marcos V., Nogueira, Tatiane, Rios, Ricardo A., Lopes, Tiago J. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206133/
https://www.ncbi.nlm.nih.gov/pubmed/37235045
http://dx.doi.org/10.3389/fbinf.2023.1152039