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TMEM16A/F support exocytosis but do not inhibit Notch-mediated goblet cell metaplasia of BCi-NS1.1 human airway epithelium

Cl(−) channels such as the Ca(2+) activated Cl(−) channel TMEM16A and the Cl(−) permeable phospholipid scramblase TMEM16F may affect the intracellular Cl(−) concentration ([Cl(−)](i)), which could act as an intracellular signal. Loss of airway expression of TMEM16A induced a massive expansion of the...

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Detalles Bibliográficos
Autores principales: Centeio, Raquel, Cabrita, Inês, Schreiber, Rainer, Kunzelmann, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10206426/
https://www.ncbi.nlm.nih.gov/pubmed/37234411
http://dx.doi.org/10.3389/fphys.2023.1157704