Cargando…

Decreasing microtubule detyrosination by parthenolide restores sodium current in mdx cardiomyocytes

FUNDING ACKNOWLEDGEMENTS: Type of funding sources: None. BACKGROUND: The cardiac sodium channel Nav1.5 is transported to the membrane by the microtubule network. Alterations in microtubule dynamics are known to impact on ion channel trafficking. Pathophysiological conditions such as heart failure an...

Descripción completa

Detalles Bibliográficos
Autores principales:	Casini, S, Nasilli, G, De Waal, T, Dekkers, Y, Van Amersfoorth, S, Marchal, G A, Rothenberg, E, Delmar, M, Remme, C A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2023
Materias:	41.4.5 - Ion Channels, Electrophysiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207065/ http://dx.doi.org/10.1093/europace/euad122.592

Ejemplares similares

Altered cardiac repolarization associated with cellular electrophysiological remodeling following chronic testosterone undecanoate administration in a canine model
por: Topal, L, et al.
Publicado: (2023)

In vivo KCNQ1-suppression-replacement gene therapy in transgenic rabbits with type 1 long QT syndrome
por: Giammarino, L, et al.
Publicado: (2023)

Cardiac digital twins of the adult population: linking electrophysiological functions to anatomy
por: Qian, S, et al.
Publicado: (2023)

Subunits α, β and γ of the epithelial Na(+) channel (ENaC) are functionally related to the hypertonicity-induced cation channel (HICC) in rat hepatocytes
por: Plettenberg, Sandra, et al.
Publicado: (2007)

Inhibition of microtubule detyrosination by parthenolide facilitates functional CNS axon regeneration
por: Leibinger, Marco, et al.
Publicado: (2023)

Suppression of tubulin detyrosination by parthenolide recruits the plant-specific kinesin KCH to cortical microtubules
por: Schneider, Natalie, et al.
Publicado: (2015)

Detyrosinated microtubule arrays drive myofibrillar malformations in mdx muscle fibers
por: Harriot, Anicca D., et al.
Publicado: (2023)

Structure of the voltage-gated potassium channel K(V)1.3: Insights into the inactivated conformation and binding to therapeutic leads
por: Chandy, K. George, et al.
Publicado: (2023)

Structural basis of PI(4,5)P(2)-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A)
por: Seebohm, Guiscard, et al.
Publicado: (2014)

Neuronal nitric oxide synthase regulation of calcium cycling in ventricular cardiomyocytes is independent of Ca(v)1.2 channel modulation under basal conditions
por: Ebner, Janine, et al.
Publicado: (2019)

A detailed characterization of the hyperpolarization-activated “funny” current (I(f)) in human-induced pluripotent stem cell (iPSC)–derived cardiomyocytes with pacemaker activity
por: Giannetti, Federica, et al.
Publicado: (2021)

Etiology and Biomechanics of Tarsometatarsal Injuries in Professional Football Players: A Video Analysis
por: Kent, Richard W., et al.
Publicado: (2014)

Clinical Implications of Changing Parameters on an Elliptical Trainer
por: Kaplan, Yonatan, et al.
Publicado: (2014)

A Comparison of the Haider Tube-Guard(®) Endotracheal Tube Holder Versus Adhesive Tape to Determine if This Novel Device Can Reduce Endotracheal Tube Movement and Prevent Unplanned Extubation
por: Buckley, Jack C., et al.
Publicado: (2016)

Retromalleolar Groove Deepening in Recurrent Peroneal Tendon Dislocation: Technique Tip
por: van Dijk, Pim A. D., et al.
Publicado: (2017)

Development and Evaluation of a Risk-Adjusted Measure of Intraoperative Hypotension in Patients Having Nonemergent, Noncardiac Surgery
por: Christensen, Anna L., et al.
Publicado: (2020)

RESULTADOS DO PERFIL DO USO DE ANTIBIÓTICOS EM UTI COVID, UTI NÃO COVID E ENFERMARIA COVID PELO MÉTODO DE ANÁLISE DE PONTO DE PREVALÊNCIA DURANTE O ANO DE 2020
por: Lima, Beatriz Santana Sá, et al.
Publicado: (2022)

Identification of Preanesthetic History Elements by a Natural Language Processing Engine
por: Suh, Harrison S., et al.
Publicado: (2022)

Cleavage of endogenous γENaC and elevated abundance of αENaC are associated with increased Na(+) transport in response to apical fluid volume expansion in human H441 airway epithelial cells
por: Tan, Chong D., et al.
Publicado: (2011)

Determinants of the voltage dependence of G protein modulation within calcium channel β subunits
por: Dresviannikov, Andriy V., et al.
Publicado: (2008)

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP
por: Mandadi, Sravan, et al.
Publicado: (2009)

The two-pore channel TPCN2 mediates NAADP-dependent Ca(2+)-release from lysosomal stores
por: Zong, Xiangang, et al.
Publicado: (2009)

HL-1 cells express an inwardly rectifying K(+) current activated via muscarinic receptors comparable to that in mouse atrial myocytes
por: Nobles, Muriel, et al.
Publicado: (2010)

Channelopathies in Ca(v)1.1, Ca(v)1.3, and Ca(v)1.4 voltage-gated L-type Ca(2+) channels
por: Striessnig, Jörg, et al.
Publicado: (2010)

Human K(ATP) channelopathies: diseases of metabolic homeostasis
por: Olson, Timothy M., et al.
Publicado: (2009)

Cardiac sodium channelopathies
por: Amin, Ahmad S., et al.
Publicado: (2009)

Physicochemical properties of pore residues predict activation gating of Ca(V)1.2: A correlation mutation analysis
por: Beyl, Stanislav, et al.
Publicado: (2010)

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S
por: Haerteis, Silke, et al.
Publicado: (2012)

α-ENaC is a functional element of the hypertonicity-induced cation channel in HepG2 cells and it mediates proliferation
por: Bondarava, Maryna, et al.
Publicado: (2009)

Functional consequences of Kir2.1/Kir2.2 subunit heteromerization
por: Panama, Brian K., et al.
Publicado: (2010)

CO(2)-dependent opening of an inwardly rectifying K(+) channel
por: Huckstepp, Robert T. R., et al.
Publicado: (2011)

Mechanosensitivity of nicotinic receptors
por: Pan, N. Clara, et al.
Publicado: (2012)

Nitric oxide lacks direct effect on TRPC5 channels but suppresses endogenous TRPC5-containing channels in endothelial cells
por: Wong, Ching-On, et al.
Publicado: (2010)

Bimodal voltage dependence of TRPA1: mutations of a key pore helix residue reveal strong intrinsic voltage-dependent inactivation
por: Wan, Xia, et al.
Publicado: (2013)

TMEM16A knockdown abrogates two different Ca(2+)-activated Cl(−) currents and contractility of smooth muscle in rat mesenteric small arteries
por: Dam, Vibeke Secher, et al.
Publicado: (2013)

The distinct roles of anion transporters Slc26a3 (DRA) and Slc26a6 (PAT-1) in fluid and electrolyte absorption in the murine small intestine
por: Xia, Weiliang, et al.
Publicado: (2013)

Anoctamin 6 differs from VRAC and VSOAC but is involved in apoptosis and supports volume regulation in the presence of Ca(2+)
por: Juul, C. A., et al.
Publicado: (2014)

TRIC-B channels display labile gating: evidence from the TRIC-A knockout mouse model
por: Venturi, Elisa, et al.
Publicado: (2013)

Characterization of distinct single-channel properties of Ca(2+) inward currents in mitochondria
por: Bondarenko, Alexander I., et al.
Publicado: (2013)

A basic residue in the proximal C-terminus is necessary for efficient activation of the M-channel subunit Kv7.2 by PI(4,5)P(2)
por: Telezhkin, Vsevolod, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_da197ndl7vsh0q3831sr2korvn