Computational high-throughput screening and in vitro approaches identify CB-006-3; A novel PI3K-BRAF(V600E) dual targeted inhibitor against melanoma

Malignant melanoma is characterized by both genetic and molecular alterations that activate phosphoinositide 3-kinase (PI3K), and RAS/BRAF pathways. In this work, through diversity-based high-throughput virtual screening we identified a lead molecule that selectively targets PI3K and BRAF(V600E) kin...

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Detalles Bibliográficos
Autores principales: TOBEIGEI, FAISAL HASSAN, GAHTANI, REEM M., SHAIKH, AHMAD, AL ALI, AMER, KAMELI, NADER, KAMLI, HOSSAM, RAJAGOPALAN, PRASANNA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tech Science Press 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207986/
https://www.ncbi.nlm.nih.gov/pubmed/37305163
http://dx.doi.org/10.32604/or.2022.025187

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10207986/
https://www.ncbi.nlm.nih.gov/pubmed/37305163
http://dx.doi.org/10.32604/or.2022.025187

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