Ranking mAb–excipient interactions in biologics formulations by NMR spectroscopy and computational approaches

Excipients are added to biopharmaceutical formulations to enhance protein stability and enable the development of robust formulations with acceptable physicochemical properties, but the mechanism by which they confer stability is not fully understood. Here, we aimed to elucidate the mechanism throug...

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Detalles Bibliográficos
Autores principales: Zhang, Chunting, Gossert, Steven T., Williams, Jonathan, Little, Michael, Barros, Marilia, Dear, Barton, Falk, Bradley, Kanthe, Ankit D., Garmise, Robert, Mueller, Luciano, Ilott, Andrew, Abraham, Anuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208151/
https://www.ncbi.nlm.nih.gov/pubmed/37218059
http://dx.doi.org/10.1080/19420862.2023.2212416

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208151/
https://www.ncbi.nlm.nih.gov/pubmed/37218059
http://dx.doi.org/10.1080/19420862.2023.2212416

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