A Very Long-acting Exatecan and Its Synergism with DNA Damage Response Inhibitors

Exatecan (Exa) is a very potent inhibitor of topoisomerase I and anticancer agent. It has been intensively studied as a single agent, a large macromolecular conjugate and as the payload component of antigen-dependent antibody–drug conjugates. The current work describes an antigen-independent conjuga...

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Detalles Bibliográficos
Autores principales: Fontaine, Shaun D., Carreras, Christopher W., Reid, Ralph R., Ashley, Gary W., Santi, Daniel V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208276/
https://www.ncbi.nlm.nih.gov/pubmed/37377899
http://dx.doi.org/10.1158/2767-9764.CRC-22-0517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208276/
https://www.ncbi.nlm.nih.gov/pubmed/37377899
http://dx.doi.org/10.1158/2767-9764.CRC-22-0517

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