Peptidomimetic antibiotics disrupt the lipopolysaccharide transport bridge of drug-resistant Enterobacteriaceae

The rise of antimicrobial resistance poses a substantial threat to our health system, and, hence, development of drugs against novel targets is urgently needed. The natural peptide thanatin kills Gram-negative bacteria by targeting proteins of the lipopolysaccharide transport (Lpt) machinery. Using...

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Detalles Bibliográficos
Autores principales: Schuster, Matthias, Brabet, Emile, Oi, Kathryn K., Desjonquères, Nicolas, Moehle, Kerstin, Le Poupon, Karen, Hell, Sophie, Gable, Stéphane, Rithié, Virginie, Dillinger, Séverine, Zbinden, Peter, Luther, Anatol, Li, Claudia, Stiegeler, Sarah, D’Arco, Carolin, Locher, Hans, Remus, Tobias, DiMaio, Selena, Motta, Paola, Wach, Achim, Jung, Françoise, Upert, Grégory, Obrecht, Daniel, Benghezal, Mohammed, Zerbe, Oliver
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208570/
https://www.ncbi.nlm.nih.gov/pubmed/37224246
http://dx.doi.org/10.1126/sciadv.adg3683

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208570/
https://www.ncbi.nlm.nih.gov/pubmed/37224246
http://dx.doi.org/10.1126/sciadv.adg3683

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