Mitochondrial protein import clogging as a mechanism of disease

Mitochondrial biogenesis requires the import of >1,000 mitochondrial preproteins from the cytosol. Most studies on mitochondrial protein import are focused on the core import machinery. Whether and how the biophysical properties of substrate preproteins affect overall import efficiency is underex...

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Detalles Bibliográficos
Autores principales: Coyne, Liam P, Wang, Xiaowen, Song, Jiyao, de Jong, Ebbing, Schneider, Karin, Massa, Paul T, Middleton, Frank A, Becker, Thomas, Chen, Xin Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208645/
https://www.ncbi.nlm.nih.gov/pubmed/37129366
http://dx.doi.org/10.7554/eLife.84330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208645/
https://www.ncbi.nlm.nih.gov/pubmed/37129366
http://dx.doi.org/10.7554/eLife.84330

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