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TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain

Vocalization is an essential medium for social signaling in birds and mammals. Periaqueductal gray (PAG) a conserved midbrain structure is believed to be responsible for innate vocalizations, but its molecular regulation remains largely unknown. Here, through a mouse forward genetic screening we ide...

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Detalles Bibliográficos
Autores principales: Qi, Huihui, Luo, Li, Lu, Caijing, Chen, Runze, Zhou, Xianyao, Zhang, Xiaohui, Jia, Yichang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10208975/
https://www.ncbi.nlm.nih.gov/pubmed/36782064
http://dx.doi.org/10.1038/s41380-023-01993-5