Inhibition of Wnt/β‐catenin signaling upregulates Na(v)1.5 channels in Brugada syndrome iPSC‐derived cardiomyocytes

The voltage‐gated Na(v)1.5 channels mediate the fast Na(+) current (I (Na)) in cardiomyocytes initiating action potentials and cardiac contraction. Downregulation of I (Na), as occurs in Brugada syndrome (BrS), causes ventricular arrhythmias. The present study investigated whether the Wnt/β‐catenin...

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Detalles Bibliográficos
Autores principales: Lu, Aizhu, Gu, Ruonan, Chu, Cencen, Xia, Ying, Wang, Jerry, Davis, Darryl R., Liang, Wenbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209518/
https://www.ncbi.nlm.nih.gov/pubmed/37226398
http://dx.doi.org/10.14814/phy2.15696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209518/
https://www.ncbi.nlm.nih.gov/pubmed/37226398
http://dx.doi.org/10.14814/phy2.15696

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