Comparing molecular and computational approaches for detecting viral integration of AAV gene therapy constructs

Many current gene therapy targets use recombinant adeno-associated virus (AAV). The majority of delivered AAV therapeutics persist as episomes, separate from host DNA, yet some viral DNA can integrate into host DNA in different proportions and at genomic locations. The potential for viral integratio...

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Detalles Bibliográficos
Autores principales: Oziolor, Elias M., Kumpf, Steven W., Qian, Jessie, Gosink, Mark, Sheehan, Mark, Rubitski, David M., Newman, Leah, Whiteley, Laurence O., Lanz, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209688/
https://www.ncbi.nlm.nih.gov/pubmed/37251978
http://dx.doi.org/10.1016/j.omtm.2023.04.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209688/
https://www.ncbi.nlm.nih.gov/pubmed/37251978
http://dx.doi.org/10.1016/j.omtm.2023.04.009

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