Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

BACKGROUND: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation. BCAA metabol...

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Detalles Bibliográficos
Autores principales: Xue, Meiting, Xiao, Jiawei, Jiang, Wenna, Wang, Yanhui, Zuo, Duo, An, Haohua, Ren, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209880/
https://www.ncbi.nlm.nih.gov/pubmed/37216755
http://dx.doi.org/10.1016/j.tranon.2023.101696

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209880/
https://www.ncbi.nlm.nih.gov/pubmed/37216755
http://dx.doi.org/10.1016/j.tranon.2023.101696

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