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Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

BACKGROUND: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation. BCAA metabol...

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Detalles Bibliográficos
Autores principales:	Xue, Meiting, Xiao, Jiawei, Jiang, Wenna, Wang, Yanhui, Zuo, Duo, An, Haohua, Ren, Li
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Neoplasia Press 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10209880/ https://www.ncbi.nlm.nih.gov/pubmed/37216755 http://dx.doi.org/10.1016/j.tranon.2023.101696

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