Dabrafenib–Panobinostat Salt: Improving the Dissolution Rate and Inhibition of BRAF Melanoma Cells

[Image: see text] Cocrystallization of the drug–drug salt-cocrystal of the histone deacetylase inhibitor (HDACi) panobinostat (PAN) and b-rapidly accelerated fibrosarcoma (BRAF) inhibitor dabrafenib (DBF) afforded single crystals of a two-drug salt stabilized by N(+)–H···O and N(+)–H···N(–) hydrogen...

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Detalles Bibliográficos
Autores principales: Rai, Sunil K., Marverti, Gaetano, Gunnam, Anilkumar, Allu, Suryanarayana, Nangia, Ashwini K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210236/
https://www.ncbi.nlm.nih.gov/pubmed/37251170
http://dx.doi.org/10.1021/acsomega.3c01881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10210236/
https://www.ncbi.nlm.nih.gov/pubmed/37251170
http://dx.doi.org/10.1021/acsomega.3c01881

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