Identification of ARUK2002821 as an isoform-selective PI5P4Kα inhibitor

The phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) play a central role in regulating cell signalling pathways and, as such, have become therapeutic targets for diseases such as cancer, neurodegeneration and immunological disorders. Many of the PI5P4Kα inhibitors that have been reported to date...

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Detalles Bibliográficos
Autores principales: Willems, Henriëtte M. G., Edwards, Simon, Boffey, Helen K., Chawner, Stephen J., Green, Christopher, Romero, Tamara, Winpenny, David, Skidmore, John, Clarke, Jonathan H., Andrews, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211317/
https://www.ncbi.nlm.nih.gov/pubmed/37252102
http://dx.doi.org/10.1039/d3md00039g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10211317/
https://www.ncbi.nlm.nih.gov/pubmed/37252102
http://dx.doi.org/10.1039/d3md00039g

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