Electron microscopy imaging and mechanical characterization of T47D multicellular tumor spheroids–Older spheroids reduce interstitial space and become stiffer

Multicellular cancer spheroids are an in vitro tissue model that mimics the three-dimensional microenvironment. As spheroids grow, they develop the gradients of oxygen, nutrients, and catabolites, affecting crucial tumor characteristics such as proliferation and treatment responses. The measurement...

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Detalles Bibliográficos
Autores principales: Madhavan, Mathangi, Jaiswal, Devina, Karlberg, Sarah, Duggan, Alexis, Almarshad, Hassan A., Claffey, Kevin P., Hoshino, Kazunori
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212087/
https://www.ncbi.nlm.nih.gov/pubmed/37228139
http://dx.doi.org/10.1371/journal.pone.0286291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212087/
https://www.ncbi.nlm.nih.gov/pubmed/37228139
http://dx.doi.org/10.1371/journal.pone.0286291

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