Hierarchical association of COPD to principal genetic components of biological systems

Many disease-causing genetic variants converge on common biological functions and pathways. Precisely how to incorporate pathway knowledge in genetic association studies is not yet clear, however. Previous approaches employ a two-step approach, in which a regular association test is first performed...

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Detalles Bibliográficos
Autores principales: Carlin, Daniel E., Larsen, Simon J., Sirupurapu, Vikram, Cho, Michael H., Silverman, Edwin K., Baumbach, Jan, Ideker, Trey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212185/
https://www.ncbi.nlm.nih.gov/pubmed/37228113
http://dx.doi.org/10.1371/journal.pone.0286064

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212185/
https://www.ncbi.nlm.nih.gov/pubmed/37228113
http://dx.doi.org/10.1371/journal.pone.0286064

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