The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Necroptosis is a mode of programmed, lytic cell death that is executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following activation by the upstream kinases, receptor-interacting serine/threonine protein kinase (RIPK)-1 and RIPK3. Dysregulated necroptosis has been implicated in th...

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Detalles Bibliográficos
Autores principales: Pierotti, Catia L., Jacobsen, Annette V., Grohmann, Christoph, Dempsey, Ruby K., Etemadi, Nima, Hildebrand, Joanne M., Fitzgibbon, Cheree, Young, Samuel N., Davies, Katherine A., Kersten, Wilhelmus J. A., Silke, John, Lowes, Kym N., Jousset Sabroux, Hélène, Huang, David C. S., van Delft, Mark F., Murphy, James M., Lessene, Guillaume
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2023
Materias:
Cell Death & Injury
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212518/
https://www.ncbi.nlm.nih.gov/pubmed/37115711
http://dx.doi.org/10.1042/BCJ20230035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212518/
https://www.ncbi.nlm.nih.gov/pubmed/37115711
http://dx.doi.org/10.1042/BCJ20230035

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