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Statistical inference reveals the role of length, GC content, and local sequence in V(D)J nucleotide trimming

To appropriately defend against a wide array of pathogens, humans somatically generate highly diverse repertoires of B cell and T cell receptors (BCRs and TCRs) through a random process called V(D)J recombination. Receptor diversity is achieved during this process through both the combinatorial asse...

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Detalles Bibliográficos
Autores principales: Russell, Magdalena L, Simon, Noah, Bradley, Philip, Matsen, Frederick A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10212571/
https://www.ncbi.nlm.nih.gov/pubmed/37227256
http://dx.doi.org/10.7554/eLife.85145